Immunological Reagents

Moredun Research Institute has a long history of producing immunological reagents that underpin research into prevention and control of infectious diseases of livestock. Gary Entrican, Colin McInnes and Sean Wattegedera (in collaboration with others at Moredun and elsewhere) have developed a panel of Chinese Hamster Ovary (CHO) cells transfected with genes or cDNAs encoding ovine and bovine cytokines and other immunomodulatory molecules. These CHO transfectants have been used to develop monoclonal antibodies (Mabs), to evaluate Mabs for intracellular staining (see below) and to definitively assess Mabs for species-cross reactivity and to produce cytokines for dendritic cell growth kits.

A list of ELISAs currently available for detecting ovine cytokines can be found to the right.

Further information on these and other veterinary immunological reagents can be found at The Immunological Toolbox  and the USDA Veterinary Immune Reagent Network. Further links to other reagent and technology resources can be found within those websites.